Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 14/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12675766 | 0.84 | HTR6 (0.39) | HTR6BRD4CCNE1CDK2HTR1A | |
| SCHEMBL1267361 | 0.80 | HTR6 (0.40) | HTR6BRD4CCNE1CDK2HTR1A | |
| SCHEMBL1266811 | 0.80 | BRD4 (0.40) | HTR6BRD4CCNE1CDK2HTR1A | |
| SCHEMBL3828152 | 0.79 | HTR6 (0.40) | HTR6BRD4CCNE1CDK2HTR1A | |
| SCHEMBL4512514 | 0.79 | MAPT (0.43) | HTR6BRD4CCNE1CDK2 | |
| SCHEMBL3947254 | 0.78 | HTR6 (0.39) | HTR6BRD4CCNE1CDK2HTR1A | |
| SCHEMBL21294221 | 0.74 | BRD4 (0.39) | HTR6BRD4CCNE1CDK2HTR1A | |
| SCHEMBL28108723 | 0.73 | HTR6 (0.39) | HTR6BRD4CCNE1CDK2HTR1A | |
| SCHEMBL2540266 | 0.73 | CYP3A4 (0.42) | HTR6BRD4CCNE1CDK2DRD2 | |
| SCHEMBL1266828 | 0.72 | HTR6 (0.38) | HTR6BRD4CCNE1CDK2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086972-A2 | COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR | PLEXXIKON, INC. (US) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008064255-A2 | COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR | PLEXXIKON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |