Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 10/20 | 0.48 |
| ▸ | PPARG | P37231 | 9/20 | 0.48 |
| ▸ | PPARD | Q03181 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3849240 | 0.98 | PPARA (0.48) | PPARAPPARGPPARDNPC1ALDH1A1 | |
| SCHEMBL3284392 | 0.90 | PPARA (0.51) | PPARAPPARGNPC1ALDH1A1KMT2A | |
| SCHEMBL3845248 | 0.90 | PLA2G4B (0.40) | PPARAPPARGNPC1ALDH1A1KMT2A | |
| SCHEMBL3845681 | 0.90 | PPARA (0.61) | PPARAPPARGPPARD | |
| SCHEMBL3849961 | 0.90 | PPARA (0.58) | PPARAPPARGPPARDNPC1ALDH1A1 | |
| SCHEMBL3844621 | 0.90 | PPARA (0.63) | PPARAPPARGPPARD | |
| SCHEMBL3846291 | 0.89 | PLA2G4B (0.40) | PPARAPPARGNPC1ALDH1A1KMT2A | |
| SCHEMBL3289722 | 0.89 | PPARA (0.51) | PPARAPPARGNPC1ALDH1A1KMT2A | |
| SCHEMBL3844604 | 0.85 | KMT2A (0.36) | PPARAPPARGNPC1ALDH1A1KMT2A | |
| SCHEMBL3842642 | 0.84 | PPARA (0.51) | PPARAPPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856065-B1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PF MEDICAMENT (FR) | 2009-11-11 | — | — | EP | claimed |
| EP-1856065-B1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PF MEDICAMENT (FR) | 2009-11-11 | — | — | EP | disclosed |