Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 6/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | BUB1 | O43683 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GNRHR | P30968 | 1/20 | 0.36 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3838222 | 0.83 | KMT2A (0.43) | KMT2AALDH1A1KDM4EPOLBPDE5A | |
| SCHEMBL596647 | 0.83 | ALDH1A1 (0.44) | KMT2AALDH1A1KDM4EPOLBPDE5A | |
| SCHEMBL3953305 | 0.73 | PDE5A (0.54) | PDE5ALMNA | |
| SCHEMBL5766056 | 0.72 | KMT2A (0.46) | KMT2AALDH1A1KDM4EPOLBPDE5A | |
| SCHEMBL2921176 | 0.70 | SMN1; SMN2 (0.52) | KMT2AALDH1A1KDM4EPOLBMAPK1 | |
| SCHEMBL16082690 | 0.69 | SMN1; SMN2 (0.52) | KMT2AALDH1A1KDM4EPOLBMAPK1 | |
| SCHEMBL29831320 | 0.69 | SMN1; SMN2 (0.52) | KMT2AALDH1A1KDM4EPOLBMAPK1 | |
| SCHEMBL17610985 | 0.68 | P2RY14 (0.50) | KMT2AALDH1A1KDM4EPOLBCYP1A2 | |
| SCHEMBL17610956 | 0.68 | SMN1; SMN2 (0.47) | KMT2AALDH1A1KDM4EPOLBMAPK1 | |
| SCHEMBL596745 | 0.68 | ADORA2A (0.46) | KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097417-A1 | NOVEL AZA-BICYCLIC COMPOUNDS AND THEIR USE AS STIMULATORS OF SOLUBLE GUANYLATE CYCLASE | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008061657-A1 | NOVEL AZA-BICYCLIC COMPOUNDS AND THEIR USE AS STIMULATORS OF SOLUBLE GUANYLATE CYCLASE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-05-29 | — | — | WO | disclosed |