Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 10/20 | 0.64 |
| ▸ | CHRNA4 | P43681 | 10/20 | 0.64 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.57 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | NCF1 | P14598 | 1/20 | 0.48 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5656901 | 0.93 | CHRNB2 (0.68) | CHRNB2CHRNA4CHRNA1CHRNA7 | |
| SCHEMBL12205345 | 0.86 | CHRNB2 (0.75) | CHRNB2CHRNA4CHRNA1CHRNA7ADRB2 | |
| SCHEMBL6094605 | 0.79 | CHRNB2 (0.78) | CHRNB2CHRNA4CHRNA1CHRNA7 | |
| SCHEMBL23458773 | 0.78 | CHRNB2 (0.69) | CHRNB2CHRNA4CHRNA1CHRNA7ADRB2 | |
| SCHEMBL3067811 | 0.78 | CHRNB2 (0.81) | CHRNB2CHRNA4CHRNA1CHRNA7 | |
| SCHEMBL5655329 | 0.78 | CHRNB2 (0.76) | CHRNB2CHRNA4CHRNA1CHRNA7 | |
| SCHEMBL5656491 | 0.78 | CHRNB2 (0.76) | CHRNB2CHRNA4CHRNA1CHRNA7 | |
| SCHEMBL11359435 | 0.78 | CHRNB2 (0.64) | CHRNB2CHRNA4CHRNA1CHRNA7 | |
| SCHEMBL17884952 | 0.78 | CHRNB2 (0.64) | CHRNB2CHRNA4CHRNA1CHRNA7ADRB2 | |
| SCHEMBL30609720 | 0.78 | CHRNB2 (0.64) | CHRNB2CHRNA4CHRNA1CHRNA7ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763351-A4 | 3-AMINOCYCLOPENTANECARBOXAMIDES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORP (US) | 2009-08-12 | — | — | EP | disclosed |
| EP-1763351-A2 | 3-AMINOCYCLOPENTANECARBOXAMIDES AS MODULATORS OF CHEMOKINE RECEPTORS | Incyte Corporation (US) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006004684-A2 | 3-AMINOCYCLOPENTANECARBOXAMIDES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORPORATION (US) | 2006-01-12 | — | — | WO | disclosed |