Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 19/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3839119 | 1.00 | CRHR1 (0.46) | CRHR1AURKARPS6KB1 | |
| SCHEMBL3845342 | 0.92 | CRHR1 (0.46) | CRHR1AURKARPS6KB1 | |
| SCHEMBL3843531 | 0.92 | CRHR1 (0.46) | CRHR1AURKARPS6KB1 | |
| SCHEMBL6649037 | 0.92 | CRHR1 (0.46) | CRHR1AURKARPS6KB1 | |
| SCHEMBL13617168 | 0.88 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL3838008 | 0.87 | CRHR1 (0.43) | CRHR1AURKARPS6KB1 | |
| SCHEMBL6669380 | 0.87 | CRHR1 (0.43) | CRHR1AURKARPS6KB1 | |
| SCHEMBL3843362 | 0.87 | CRHR1 (0.41) | CRHR1AURKARPS6KB1 | |
| SCHEMBL3842498 | 0.87 | AURKA (0.44) | CRHR1AURKARPS6KB1 | |
| SCHEMBL6643610 | 0.82 | CRHR1 (0.46) | CRHR1AURKARPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1446387-B1 | SUBSTITUTED ARYL 1,4-PYRAZINE DERIVATIVES | PHARMACIA & UPJOHN CO LLC (US) | 2009-11-04 | — | — | EP | disclosed |