Diphenylacetylene

Diphenylacetylene

SCHEMBL3842452

C(#Cc1ccccc1)c1ccccc1.C[Si](C)(C)C#Cc1ccccc1

nearest known ligand 0.60

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APP P05067 1/20 0.60
GRM5 P41594 9/20 0.50
NPC1 O15118 4/20 0.50
RAB9A P51151 3/20 0.50
SMN1; SMN2 Q16637 3/20 0.50
KDM4E B2RXH2 2/20 0.50
MEN1 O00255 2/20 0.50
ALDH1A1 P00352 2/20 0.50
CYP1A2 P05177 2/20 0.50
CYP3A4 P08684 2/20 0.50
CYP2C9 P11712 2/20 0.50
HPGD P15428 2/20 0.50
CYP2C19 P33261 2/20 0.50
KMT2A Q03164 2/20 0.50
TP53 P04637 1/20 0.50
CYP2D6 P10635 1/20 0.50
PKM P14618 1/20 0.50
ALOX15 P16050 1/20 0.50
THPO P40225 1/20 0.50
GRIN2B Q13224 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL712499 0.98 APP (0.57) APPGRM5NPC1RAB9ASMN1; SMN2
SCHEMBL563613 0.97 APP (0.55) APPGRM5NPC1RAB9ASMN1; SMN2
SCHEMBL23867871 0.91 APP (0.50) APPGRM5NPC1RAB9ASMN1; SMN2
SCHEMBL5249596 0.89 APP (0.52) APPGRM5NPC1RAB9ASMN1; SMN2
SCHEMBL5248505 0.89 APP (0.52) APPGRM5NPC1RAB9ASMN1; SMN2
SCHEMBL1306505 0.87 APP (0.41) APPGRM5NPC1RAB9ASMN1; SMN2
SCHEMBL6535646 0.87 NPC1 (0.50) APPGRM5NPC1RAB9ASMN1; SMN2
Acetic Acid SCHEMBL28180146 0.87 FFAR1 (0.46) APPGRM5NPC1RAB9ASMN1; SMN2
SCHEMBL15398375 0.87 APP (0.44) APPGRM5NPC1RAB9ASMN1; SMN2
SCHEMBL12477508 0.84 CYP1A2 (0.59) APPGRM5NPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1245638-B1 Composition for insulating film formation JSR CORP (JP) 2009-01-14 EP disclosed
US-6852370-B2 Composition for film formation and material for insulating film formation JSR CORPORATION (JP) 2005-02-08 US disclosed
US-20020172652-A1 Composition for film formation and material for insulating film formation JSR CORPORATION (JP) 2002-11-21 US disclosed
EP-1245638-A1 Composition for insulating film formation JSR Corporation (JP) 2002-10-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020172652-A1 Composition for film formation and material for insulating film formation VCL, BMI1, PUF60 APP 687/4885GRM5 4349/4885NPC1 3853/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.