Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4552437 | 0.87 | CHRNA7 (0.61) | CHRNA7PTGS2 | |
| SCHEMBL3823054 | 0.82 | PTGS2 (0.70) | PTGS2 | |
| SCHEMBL3031000 | 0.80 | CHRNA7 (0.98) | CHRNA7 | |
| SCHEMBL4092136 | 0.78 | — | — | |
| SCHEMBL3030312 | 0.78 | CHRNA7 (0.68) | CHRNA7 | |
| SCHEMBL3824225 | 0.78 | PTGS2 (0.78) | PTGS2 | |
| SCHEMBL15072650 | 0.77 | PTGS2 (0.66) | CHRNA7PTGS2 | |
| SCHEMBL4097193 | 0.77 | PTGS2 (0.59) | PTGS2 | |
| SCHEMBL3824188 | 0.76 | PTGS2 (0.56) | CHRNA7PTGS2 | |
| SCHEMBL3824305 | 0.76 | PTGS2 (0.54) | CHRNA7PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7906551-B2 | 3-substituted-1,5-diarly-2-alkyl-pyrroles highly selective and orally effective COX-2 inhibitors | ROTTAPHARM S.P.A. (IT) | 2011-03-15 | — | — | US | disclosed |
| US-20090264500-A1 | 3-SUBSTITUTED-1,5-DIARLY-2-ALKYL-PYRROLES HIGHLY SELECTIVE AND ORALLY EFFECTIVE COX-2 INHIBITORS | ROTTAPHARM BIOTECH S.R.L. (IT) | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264500-A1 | 3-SUBSTITUTED-1,5-DIARLY-2-ALKYL-PYRROLES HIGHLY SELECTIVE AND ORALLY EFFECTIVE COX-2 INHIBITORS | PTGS2, PTGS1, PTGES2 | CHRNA7 4269/4885PTGS2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.