Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.40 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.36 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.31 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.31 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.31 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3842600 | 1.00 | TSHR (0.41) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL5565794 | 0.85 | TSHR (0.50) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL31445647 | 0.85 | TSHR (0.50) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL6690087 | 0.85 | TSHR (0.50) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL7556436 | 0.82 | FFAR3 (0.33) | FFAR3GRIK1GRIA4GRIK3GRIK5 | |
| SCHEMBL11809374 | 0.77 | TSHR (0.41) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL11740585 | 0.77 | TSHR (0.41) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL10505521 | 0.76 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL10505511 | 0.76 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL20564435 | 0.74 | HCAR2 (0.39) | TSHRTP53EGLN1EGLN3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615543-B2 | Complexes with C-reactive protein (CRP) molecules; rheumatoid arthritis, juvenile chronic (rheumatoid) arthritis, ankylosing spondylitis, psoriatic arthritis, systemic vasculitis, polymyalgia rheumatica, Reiter's disease, Crohn's disease and familial Mediterranean fever | PENTRAXIN THERAPEUTICS LIMITED (GB) | 2009-11-10 | — | — | US | disclosed |
| EP-1503800-B1 | TREATMENT AND PREVENTION OF TISSUE DAMAGE ASSOCIATED WITH INCREASED C-REACTIVE PROTEIN PRODUCTION | PENTRAXIN THERAPEUTICS LTD (GB) | 2009-10-28 | — | — | EP | disclosed |
| US-20060019930-A1 | Treatment and prevention of tissue damage | PENTRAXIN THERAPEUTICS LIMITED (GB) | 2006-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060019930-A1 | Treatment and prevention of tissue damage | TTR, RBP1, SERPINA6 | TSHR 1704/4885TP53 549/4885EGLN1 4410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.