Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3842656 | 1.00 | CHRNA7 (0.50) | CHRNA7TLR7CHRM2CHRM1CHRM3 | |
| SCHEMBL16642060 | 0.92 | CHRNA7 (0.46) | CHRNA7TLR7CHRM2CHRM1CHRM3 | |
| SCHEMBL999949 | 0.91 | CHRNA7 (0.50) | CHRNA7TLR7CHRM2CHRM1CHRM3 | |
| SCHEMBL999950 | 0.91 | CHRNA7 (0.50) | CHRNA7TLR7CHRM2CHRM1CHRM3 | |
| SCHEMBL3839991 | 0.90 | CHRM3 (0.47) | CHRNA7TLR7CHRM2CHRM1CHRM3 | |
| SCHEMBL3839987 | 0.90 | CHRM3 (0.47) | CHRNA7TLR7CHRM2CHRM1CHRM3 | |
| SCHEMBL3840602 | 0.86 | CHRNA7 (0.50) | CHRNA7CHRM2CHRM1CHRM3ALDH1A1 | |
| SCHEMBL3840605 | 0.86 | CHRNA7 (0.50) | CHRNA7CHRM2CHRM1CHRM3ALDH1A1 | |
| SCHEMBL3839437 | 0.85 | CHRNA7 (0.44) | CHRNA7TLR7CHRM2CHRM1CHRM3 | |
| SCHEMBL3839425 | 0.85 | CHRNA7 (0.44) | CHRNA7TLR7CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537104-B1 | AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | claimed |
| US-9012451-B2 | Aza-bicycloalkyl ethers and their use as ALPHA7-nachr agonists | NOVARTIS AG (CH) | 2015-04-21 | — | — | US | disclosed |
| US-9012451-B2 | Aza-bicycloalkyl ethers and their use as ALPHA7-nachr agonists | NOVARTIS AG (CH) | 2015-04-21 | — | — | US | disclosed |