SCHEMBL3840602

SCHEMBL3840602

Cc1ccc(Cl)c(-c2cnc(O[C@H]3CN4CCC3CC4)nc2)c1

nearest known ligand 0.50

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 1/20 0.50
ALDH1A1 P00352 1/20 0.40
CHRM2 P08172 4/20 0.40
CHRM1 P11229 4/20 0.40
CHRM3 P20309 3/20 0.40
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
TSHR P16473 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38
GAA P10253 1/20 0.38
ATM Q13315 1/20 0.38
LSS P48449 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3840605 1.00 CHRNA7 (0.50) CHRNA7ALDH1A1CHRM2CHRM1CHRM3
SCHEMBL3842246 0.91 CHRNA7 (0.50) CHRNA7ALDH1A1CHRM2CHRM1CHRM3
SCHEMBL3842249 0.91 CHRNA7 (0.50) CHRNA7ALDH1A1CHRM2CHRM1CHRM3
SCHEMBL3842109 0.88 TSHR (0.45) CHRNA7CHRM2CHRM1CHRM3TSHR
SCHEMBL3842111 0.88 TSHR (0.45) CHRNA7CHRM2CHRM1CHRM3TSHR
SCHEMBL3842653 0.86 CHRNA7 (0.50) CHRNA7ALDH1A1CHRM2CHRM1CHRM3
SCHEMBL3842656 0.86 CHRNA7 (0.50) CHRNA7ALDH1A1CHRM2CHRM1CHRM3
SCHEMBL3840297 0.84 GAA (0.44) CHRNA7CHRM2CHRM1CHRM3GAA
SCHEMBL3840299 0.84 GAA (0.44) CHRNA7CHRM2CHRM1CHRM3GAA
SCHEMBL999950 0.84 CHRNA7 (0.50) CHRNA7ALDH1A1CHRM2CHRM1CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9012451-B2 Aza-bicycloalkyl ethers and their use as ALPHA7-nachr agonists NOVARTIS AG (CH) 2015-04-21 US claimed
EP-1537104-B1 AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS NOVARTIS AG (CH) 2009-11-11 EP claimed
US-9012451-B2 Aza-bicycloalkyl ethers and their use as ALPHA7-nachr agonists NOVARTIS AG (CH) 2015-04-21 US disclosed
US-9012451-B2 Aza-bicycloalkyl ethers and their use as ALPHA7-nachr agonists NOVARTIS AG (CH) 2015-04-21 US disclosed