Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 13/20 | 0.46 |
| ▸ | PPARA | Q07869 | 10/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.41 |
| ▸ | PPARD | Q03181 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3841090 | 0.97 | PPARG (0.47) | PPARGPPARAPSEN1PSEN2APH1B | |
| SCHEMBL3846393 | 0.91 | TP53 (0.39) | PPARGPPARATP53TSHRPLA2G4B | |
| SCHEMBL3286062 | 0.90 | PPARA (0.40) | PPARGPPARATSHR | |
| SCHEMBL3842276 | 0.89 | TP53 (0.39) | PPARGPPARATP53TSHRPLA2G4B | |
| SCHEMBL3841493 | 0.88 | PPARA (0.47) | PPARGPPARAPSEN1PSEN2APH1B | |
| SCHEMBL3842497 | 0.88 | PPARA (0.53) | PPARGPPARAPPARD | |
| SCHEMBL3285407 | 0.88 | PPARA (0.41) | PPARGPPARATSHR | |
| SCHEMBL3844301 | 0.85 | PPARG (0.39) | PPARGPPARAPPARD | |
| SCHEMBL3844532 | 0.85 | PPARA (0.45) | PPARGPPARAPSEN1PSEN2APH1B | |
| SCHEMBL3845476 | 0.84 | MAPK14 (0.39) | PPARGPPARATP53TSHRPLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856065-B1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PF MEDICAMENT (FR) | 2009-11-11 | — | — | EP | claimed |
| EP-1856065-B1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PF MEDICAMENT (FR) | 2009-11-11 | — | — | EP | disclosed |
| EP-1856065-A1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PIERRE FABRE MEDICAMENT (FR) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006092507-A1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PIERRE FABRE MEDICAMENT (FR) | 2006-09-08 | — | — | WO | disclosed |