Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 15/20 | 0.57 |
| ▸ | PPARG | P37231 | 12/20 | 0.57 |
| ▸ | PPARD | Q03181 | 6/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3844923 | 0.96 | PPARA (0.59) | PPARAPPARGPPARDCYP4F2CYP4A11 | |
| SCHEMBL3848017 | 0.95 | PPARA (0.61) | PPARAPPARGPPARDCYP4F2CYP4A11 | |
| SCHEMBL3845333 | 0.91 | PPARA (0.46) | PPARAPPARGPPARDCYP2D6LMNA | |
| SCHEMBL3288346 | 0.91 | PPARA (0.59) | PPARAPPARGPPARDCYP2D6LMNA | |
| SCHEMBL3843762 | 0.90 | PPARA (0.50) | PPARAPPARGPPARD | |
| SCHEMBL3840894 | 0.89 | PPARA (0.45) | PPARAPPARGPPARDCYP4F2CYP4A11 | |
| SCHEMBL3841451 | 0.88 | PPARA (0.58) | PPARAPPARGPPARDCYP4F2CYP4A11 | |
| SCHEMBL3843334 | 0.88 | PPARA (0.60) | PPARAPPARGPPARDCYP4F2CYP4A11 | |
| SCHEMBL3842503 | 0.88 | PPARA (0.52) | PPARAPPARGPPARDCYP2D6 | |
| SCHEMBL3844032 | 0.87 | PPARA (0.58) | PPARAPPARGPPARDCYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856065-B1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PF MEDICAMENT (FR) | 2009-11-11 | — | — | EP | claimed |
| EP-1856065-B1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PF MEDICAMENT (FR) | 2009-11-11 | — | — | EP | disclosed |
| EP-1856065-A1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PIERRE FABRE MEDICAMENT (FR) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006092507-A1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PIERRE FABRE MEDICAMENT (FR) | 2006-09-08 | — | — | WO | disclosed |