Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.57 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GGT1 | P19440 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7996235 | 0.99 | PTGS2 (0.56) | PTGS2PPARGPPARATHRATHRB | |
| SCHEMBL7984445 | 0.99 | PTGS2 (0.56) | PTGS2PPARGPPARATHRATHRB | |
| SCHEMBL7996167 | 0.99 | PTGS2 (0.56) | PTGS2PPARGPPARATHRATHRB | |
| SCHEMBL6534901 | 0.96 | PTGS2 (0.56) | PTGS2PPARGPPARATHRATHRB | |
| SCHEMBL6535167 | 0.91 | PTGS2 (0.54) | PTGS2PPARGPPARATHRATHRB | |
| SCHEMBL7705224 | 0.88 | PTGS2 (0.47) | PTGS2PPARGPPARATHRATHRB | |
| SCHEMBL7994631 | 0.87 | PTGS2 (0.47) | PTGS2PPARGPPARATHRATHRB | |
| SCHEMBL7998380 | 0.87 | PTGS2 (0.43) | PTGS2PPARGPPARATHRATHRB | |
| SCHEMBL7998197 | 0.85 | PTGS2 (0.49) | PTGS2PPARGPPARATHRATHRB | |
| SCHEMBL7984319 | 0.85 | PTGS2 (0.52) | PTGS2PPARGPPARATHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958275-A4 | SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 | UNIV VANDERBILT (US) | 2004-12-01 | — | — | EP | claimed |
| US-6284918-B1 | ENZYME INHIBITORS | VANDERBILT UNIVERSITY | 2001-09-04 | — | — | US | claimed |
| EP-0958275-A1 | SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 | VANDERBILT UNIVERSITY (US) | 1999-11-24 | — | — | EP | claimed |
| US-5973191-A | AN ACETOXYPHENYLALKYL SULFIDE, SALT OR HYDRATE | VANDERBILT UNIVERSITY (US) | 1999-10-26 | — | — | US | claimed |
| WO-1998029382-A1 | SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 | VANDERBILT UNIVERSITY (US) | 1998-07-09 | — | — | WO | claimed |
| US-20210196731-A1 | COMPOSITIONS AND METHODS FOR TREATING OCULAR INFLAMMATION AND OCULAR SCARRING | ARMSTRONG JAMES JACOB BRUVALL (CA) | 2021-07-01 | — | — | US | disclosed |
| EP-3801624-A1 | COMPOSITIONS AND METHODS FOR TREATING OCULAR INFLAMMATION AND OCULAR SCARRING | Armstrong, James Jacob Bruvall (CA) | 2021-04-14 | — | — | EP | disclosed |
| WO-2019227207-A1 | COMPOSITIONS AND METHODS FOR TREATING OCULAR INFLAMMATION AND OCULAR SCARRING | ARMSTRONG JAMES JACOB BRUVALL (CA) | 2019-12-05 | — | — | WO | disclosed |
| US-20090252678-A1 | COX-2-TARGETED IMAGING AGENTS | VANDERBILT UNIVERSITY (US) | 2009-10-08 | — | — | US | disclosed |
| EP-2040699-A2 | METHODS AND COMPOSITIONS FOR DIAGNOSTIC AND THERAPEUTIC TARGETING OF COX-2 | Vanderbilt University Medical Center (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2007149456-A2 | METHODS AND COMPOSITIONS FOR DIAGNOSTIC AND THERAPEUTIC TARGETING OF COX-2 | VANDERBILT UNIVERSITY (US) | 2007-12-27 | — | — | WO | disclosed |
| EP-1638612-A2 | COX-2-TARGETED IMAGING AGENTS | Vanderbilt University (US) | 2006-03-29 | — | — | EP | disclosed |
| US-6387959-B1 | ADINISTERING A SULFUR CONTAINING BENZOIC ACID ESTER | UNIVERSITEIT UTRECHT (NL) | 2002-05-14 | — | — | US | disclosed |
| EP-1194141-A1 | ANTIVIRAL THERAPY | Universitair Medisch Centrum Utrecht (NL) | 2002-04-10 | — | — | EP | disclosed |
| US-6284918-B1 | ENZYME INHIBITORS | VANDERBILT UNIVERSITY | 2001-09-04 | — | — | US | disclosed |
| WO-2001001985-A1 | ANTIVIRAL THERAPY | UNIVERSITAIR MEDISCH CENTRUM UTRECHT (NL) | 2001-01-11 | — | — | WO | disclosed |
| EP-1064940-A1 | Antiviral therapy | Universitair Medisch Centrum Utrecht (NL) | 2001-01-03 | — | — | EP | disclosed |
| EP-0958275-A1 | SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 | VANDERBILT UNIVERSITY (US) | 1999-11-24 | — | — | EP | disclosed |
| US-5973191-A | AN ACETOXYPHENYLALKYL SULFIDE, SALT OR HYDRATE | VANDERBILT UNIVERSITY (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1998029382-A1 | SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 | VANDERBILT UNIVERSITY (US) | 1998-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090252678-A1 | COX-2-TARGETED IMAGING AGENTS | PTGS2, PTGES2, PTGER2 | PTGS2 1/4885PPARG 245/4885PPARA 323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.