Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3837300 | 0.86 | SPR (0.39) | SPRHPGDEGLN1ALDH1A1KMT2A | |
| SCHEMBL3840046 | 0.86 | SPR (0.39) | SPRHPGDEGLN1ALDH1A1KMT2A | |
| SCHEMBL1626700 | 0.85 | SPR (0.40) | SPRHSD17B10KDM4EHPGDEGLN1 | |
| SCHEMBL12720415 | 0.84 | SPR (0.43) | SPRHSD17B10TSHRHTTHPGD | |
| SCHEMBL1627865 | 0.84 | SPR (0.45) | SPRHSD17B10HPGDEGLN1ALDH1A1 | |
| SCHEMBL3837301 | 0.79 | CACNA1F (0.37) | SPRHTTNPC1RAB9AEGLN1 | |
| SCHEMBL1626346 | 0.75 | SPR (0.46) | SPRTSHRHTTKDM4EHPGD | |
| SCHEMBL3861436 | 0.74 | SPR (0.48) | SPRTSHRHTTKDM4ENPC1 | |
| SCHEMBL1626634 | 0.73 | SPR (0.43) | SPRHSD17B10TSHRKDM4EHPGD | |
| SCHEMBL3864206 | 0.73 | TSHR (0.31) | TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111399-A2 | NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF | Amgen Inc. (US) | 2009-10-28 | — | — | EP | disclosed |
| WO-2008076427-A2 | NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF | AMGEN INC. (US) | 2008-06-26 | — | — | WO | disclosed |