Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.49 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1952042 | 0.93 | MET (0.55) | METCDKL5PIK3CDHTR1APIK3R1 | |
| SCHEMBL1953604 | 0.92 | MET (0.44) | METCDKL5KDM1A | |
| SCHEMBL1951995 | 0.86 | MET (0.53) | METCDKL5PIK3CDHTR1APIK3R1 | |
| SCHEMBL1951680 | 0.84 | MET (0.67) | METCDKL5 | |
| SCHEMBL837534 | 0.82 | MET (0.56) | METCDKL5 | |
| SCHEMBL1953122 | 0.82 | MET (0.54) | METCDKL5 | |
| SCHEMBL31181369 | 0.81 | MET (0.44) | METCDKL5 | |
| SCHEMBL1953493 | 0.81 | MET (0.44) | METCDKL5 | |
| SCHEMBL1952687 | 0.80 | MET (0.52) | METCDKL5 | |
| SCHEMBL12547681 | 0.80 | MET (0.52) | METCDKL5DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099447-A1 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS | Incyte Corporation (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008064157-A1 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2008-05-29 | — | — | WO | disclosed |