Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 7/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3859067 | 0.95 | PTGES (0.51) | PTGESFFAR1EPHX1EPHX2FFAR4 | |
| SCHEMBL3843278 | 0.84 | PTGES (0.54) | PTGESFFAR1EPHX1EPHX2L3MBTL1 | |
| SCHEMBL612635 | 0.83 | PTGES (0.47) | PTGESMTNR1AMTNR1B | |
| SCHEMBL10279958 | 0.81 | PTGES (0.45) | PTGESFFAR1EPHX1EPHX2FFAR4 | |
| SCHEMBL3860260 | 0.80 | PTGES (0.46) | PTGES | |
| SCHEMBL232874 | 0.79 | PTGES (0.46) | PTGESFFAR1EPHX1FFAR4MTNR1A | |
| SCHEMBL13908245 | 0.79 | PTGES (0.47) | PTGESFFAR1FFAR4MTNR1AMTNR1B | |
| SCHEMBL611662 | 0.79 | FFAR1 (0.49) | PTGESFFAR1EPHX1EPHX2L3MBTL1 | |
| SCHEMBL237780 | 0.78 | PTGES (0.45) | PTGESFFAR1EPHX1EPHX2FFAR4 | |
| SCHEMBL3863964 | 0.78 | PTGES (0.48) | PTGESKDM4EPOLBMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111223-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-10-28 | — | — | EP | disclosed |
| WO-2009058216-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-05-07 | — | — | WO | disclosed |