Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.38 |
| ▸ | PDE4A | P27815 | 3/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | RBP4 | P02753 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GRK2 | P25098 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL918227 | 0.89 | MEN1 (0.39) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3843402 | 0.87 | PDE4B (0.37) | PDE4BPDE4APDE4CPDE4DHTT | |
| SCHEMBL916480 | 0.84 | PDE4B (0.38) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5048063 | 0.84 | PDE4B (0.38) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL917169 | 0.82 | PDE4D (0.38) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL916979 | 0.80 | PDE4B (0.39) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4140485 | 0.80 | PDE4D (0.40) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL917329 | 0.79 | PDE4D (0.51) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL917973 | 0.79 | PDE4D (0.41) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL917232 | 0.78 | PDE4D (0.36) | PDE4BPDE4APDE4CPDE4DPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086948-A2 | INHIBITORS OF PHOSPHODIESTERASE TYPE-IV | Ranbaxy Laboratories Limited (IN) | 2009-08-12 | — | — | EP | claimed |
| WO-2008035315-A2 | INHIBITORS OF PHOSPHODIESTERASE TYPE-IV | RANBAXY LABORATORIES LIMITED (IN) | 2008-03-27 | — | — | WO | claimed |