Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 12/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.35 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3844053 | 0.86 | CRHR1 (0.41) | CRHR1HSD11B1F2RL3 | |
| SCHEMBL3843993 | 0.83 | CRHR1 (0.37) | CRHR1HSD11B1F2RL3 | |
| SCHEMBL3365798 | 0.80 | CRHR1 (0.49) | CRHR1HSD11B1F2RL3 | |
| SCHEMBL3846212 | 0.80 | CRHR1 (0.44) | CRHR1HSD11B1 | |
| SCHEMBL3839883 | 0.79 | CRHR1 (0.42) | CRHR1HSD11B1 | |
| SCHEMBL3839904 | 0.76 | CRHR1 (0.41) | CRHR1HSD11B1 | |
| SCHEMBL13617633 | 0.76 | CRHR1 (0.41) | CRHR1HSD11B1F2RL3 | |
| SCHEMBL3838898 | 0.76 | CRHR1 (0.41) | CRHR1HSD11B1F2RL3 | |
| SCHEMBL3838897 | 0.76 | CRHR1 (0.41) | CRHR1HSD11B1F2RL3 | |
| SCHEMBL3843725 | 0.75 | CRHR1 (0.39) | CRHR1HSD11B1F2RL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007753-B1 | HETEROCYCLIC GABA ALPHA SUBTYPE SELECTIVE RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2009-11-11 | — | — | EP | disclosed |