Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | OXER1 | Q8TDS5 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4467286 | 0.78 | DAO (0.47) | DAOMCL1ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL4551133 | 0.78 | DAO (0.51) | DAOMCL1ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL29780995 | 0.77 | DAO (0.65) | DAOMCL1ALDH1A1TSHRCCR2 | |
| SCHEMBL3842692 | 0.77 | DAO (0.46) | DAOMCL1ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL30343692 | 0.77 | MCL1 (0.49) | DAOMCL1ALDH1A1TSHROXER1 | |
| SCHEMBL17422801 | 0.77 | DAO (0.46) | DAOMCL1ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL5967722 | 0.77 | MCL1 (0.49) | DAOMCL1ALDH1A1TSHROXER1 | |
| SCHEMBL3638561 | 0.77 | DAO (0.65) | DAOMCL1ALDH1A1TSHRCCR2 | |
| SCHEMBL3672379 | 0.77 | DAO (0.42) | DAOMCL1ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL21359324 | 0.75 | SLC22A12 (0.37) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3389664-A1 | CAFFEINE INHIBITORS OF MTHFD2 AND USES THEREOF | Raze Therapeutics Inc. (US) | 2018-10-24 | — | — | EP | disclosed |
| WO-2017106352-A1 | CAFFEINE INHIBITORS OF MTHFD2 AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-06-22 | — | — | WO | disclosed |
| EP-2099799-A1 | SPIRO-PIPERIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008068159-A1 | SPIRO-PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | disclosed |