Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 2/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6405000 | 1.00 | CYP1A2 (0.46) | CYP1A2POLBCYP3A4CYP2C19HSD17B10 | |
| SCHEMBL2709135 | 0.87 | HPGD (0.50) | CYP1A2POLBCYP3A4CYP2C19HSD17B10 | |
| SCHEMBL2496643 | 0.87 | HSD17B10 (0.50) | CYP1A2POLBCYP3A4CYP2C19HSD17B10 | |
| SCHEMBL13462044 | 0.87 | HPGD (0.50) | CYP1A2POLBCYP3A4CYP2C19HSD17B10 | |
| SCHEMBL7142429 | 0.86 | HPGD (0.52) | CYP1A2POLBCYP3A4CYP2C19HSD17B10 | |
| SCHEMBL26453444 | 0.85 | CYP1A2 (0.46) | CYP1A2POLBCYP3A4CYP2C19HSD17B10 | |
| SCHEMBL25254751 | 0.84 | CYP1A2 (0.45) | CYP1A2POLBCYP3A4CYP2C19HSD17B10 | |
| SCHEMBL8426484 | 0.84 | RECQL (0.54) | CYP1A2POLBCYP3A4CYP2C19HSD17B10 | |
| SCHEMBL13567832 | 0.84 | RECQL (0.54) | CYP1A2POLBCYP3A4CYP2C19HSD17B10 | |
| SCHEMBL13567876 | 0.84 | RECQL (0.54) | CYP1A2POLBCYP3A4CYP2C19HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753748-B1 | PROLINE DERIVATIVES AND THEIR USE AS DIPEPTIDYL PEPTIDASE IV INHIBITORS | PFIZER PROD INC (US) | 2009-07-29 | — | — | EP | disclosed |
| US-7465732-B2 | (2S,4S)-4-(piperazin-1-yl)pyrrolidine-2-methanone derivatives | PFIZER INC (US) | 2008-12-16 | — | — | US | disclosed |
| US-7291618-B2 | Therapeutic compounds | PFIZER INC (US) | 2007-11-06 | — | — | US | disclosed |
| US-20070099897-A1 | Therapeutic compounds | PFIZER INC | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099897-A1 | Therapeutic compounds | SLC5A2, SLC5A1, REN | CYP1A2 1199/4885POLB 4687/4885CYP3A4 2073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.