⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21877563 | 0.86 | — | — | |
| SCHEMBL15691229 | 0.80 | — | — | |
| SCHEMBL14767317 | 0.80 | — | — | |
| SCHEMBL3846314 | 0.76 | — | — | |
| SCHEMBL21877566 | 0.76 | — | — | |
| SCHEMBL21878549 | 0.75 | — | — | |
| SCHEMBL21880230 | 0.73 | — | — | |
| SCHEMBL16154682 | 0.72 | — | — | |
| SCHEMBL19262300 | 0.70 | — | — | |
| SCHEMBL10792702 | 0.69 | ALDH1A1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200108050-A1 | METHODS FOR TREATING DISEASES | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2020-04-09 | — | — | US | claimed |
| WO-2014039860-A2 | COMPOSITIONS AND METHODS FOR MODULATING DNMT1 INHIBITOR ACTIVITY | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2014-03-13 | — | — | WO | claimed |
| US-8207381-B2 | 1-Bromo-1,1-difluoro-non-2-yn-4-ol; 6-Bromo-6,6-difluoro-2,2-dimethyl-hex-4-yn-3-ol; anticarcinogenic, -tumor, -metastasic agents; enzyme inhibitors of modification methylases; myelodysplastic syndrome, leukemia, a solid tumor, schizophrenia, sickle cell disease, or lupus; breast, colon, brain cancers | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION (US) | 2012-06-26 | — | — | US | claimed |
| US-20080188570-A1 | THERAPEUTIC COMPOUNDS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION | 2008-08-07 | — | — | US | claimed |
| US-11679098-B2 | Methods for treating diseases | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2023-06-20 | — | — | US | disclosed |
| US-11679098-B2 | Methods for treating diseases | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2023-06-20 | — | — | US | disclosed |
| US-20200108050-A1 | METHODS FOR TREATING DISEASES | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2020-04-09 | — | — | US | disclosed |
| US-9737493-B2 | Compositions and methods for modulating DNMT1 inhibitor activity | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2017-08-22 | — | — | US | disclosed |
| US-20150238439-A1 | COMPOSITIONS AND METHODS FOR MODULATING DNMT1 INHIBITOR ACTIVITY | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. | 2015-08-27 | — | — | US | disclosed |
| US-8703829-B2 | Therapeutic compounds | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2014-04-22 | — | — | US | disclosed |
| WO-2014039860-A2 | COMPOSITIONS AND METHODS FOR MODULATING DNMT1 INHIBITOR ACTIVITY | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2014-03-13 | — | — | WO | disclosed |
| EP-2567950-A1 | Substituted alkine derivatives as anti-cancer agents | University Of Louisville Research Foundation, Inc. (US) | 2013-03-13 | — | — | EP | disclosed |
| US-20120329866-A1 | THERAPEUTIC COMPOUNDS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION (US) | 2012-12-27 | — | — | US | disclosed |
| US-8207381-B2 | 1-Bromo-1,1-difluoro-non-2-yn-4-ol; 6-Bromo-6,6-difluoro-2,2-dimethyl-hex-4-yn-3-ol; anticarcinogenic, -tumor, -metastasic agents; enzyme inhibitors of modification methylases; myelodysplastic syndrome, leukemia, a solid tumor, schizophrenia, sickle cell disease, or lupus; breast, colon, brain cancers | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION (US) | 2012-06-26 | — | — | US | disclosed |
| EP-2111385-A2 | SUBSTITUTED ALKINE DERIVATIVES AS ANTI-CANCER AGENTS | University Of Louisville Research Foundation, Inc. (US) | 2009-10-28 | — | — | EP | disclosed |
| WO-2008098077-A2 | SUBSTITUTED ALKINE DERIVATIVES AS ANTI-CANCER AGENTS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION (US) | 2008-08-14 | — | — | WO | disclosed |
| US-20080188570-A1 | THERAPEUTIC COMPOUNDS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION | 2008-08-07 | — | — | US | disclosed |