Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.41 |
| ▸ | PPARA | Q07869 | 6/20 | 0.41 |
| ▸ | PPARD | Q03181 | 3/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | CNOT7 | Q9UIV1 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | USP1 | O94782 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3284180 | 0.92 | PPARG (0.40) | PPARGPPARAPPARDTBXAS1S1PR1 | |
| SCHEMBL3845660 | 0.90 | S1PR1 (0.36) | PPARGPPARAPPARDS1PR1S1PR3 | |
| SCHEMBL3284733 | 0.89 | ALDH1A1 (0.35) | PPARGPPARAPPARDCNOT7ALDH1A1 | |
| SCHEMBL3841974 | 0.89 | PPARG (0.38) | PPARGPPARAPPARDCNOT7MEN1 | |
| SCHEMBL3284376 | 0.87 | PPARG (0.38) | PPARGPPARAPPARDTBXAS1S1PR1 | |
| SCHEMBL3845476 | 0.86 | MAPK14 (0.39) | PPARGPPARAALDH1A1TP53MAPK1 | |
| SCHEMBL3285318 | 0.86 | PPARG (0.41) | PPARGPPARAPPARDTBXAS1S1PR1 | |
| SCHEMBL3284328 | 0.85 | PPARG (0.34) | PPARGPPARAPPARDS1PR1S1PR3 | |
| SCHEMBL3840290 | 0.85 | PPARG (0.39) | PPARGPPARAPPARDCNOT7TP53 | |
| SCHEMBL3842497 | 0.83 | PPARA (0.53) | PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856065-B1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PF MEDICAMENT (FR) | 2009-11-11 | — | — | EP | claimed |
| EP-1856065-B1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PF MEDICAMENT (FR) | 2009-11-11 | — | — | EP | disclosed |