Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.70 |
| ▸ | PDE3B | Q13370 | 9/20 | 0.70 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.70 |
| ▸ | TSHR | P16473 | 6/20 | 0.70 |
| ▸ | LMNA | P02545 | 4/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.70 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.70 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.70 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | THPO | P40225 | 1/20 | 0.70 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.70 |
| ▸ | BLM | P54132 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9368060 | 0.84 | PDE3B (0.74) | ALDH1A1PDE3BPDE3ATSHRLMNA | |
| Cilostazol SCHEMBL1818013 | 0.83 | PDE3B (1.00) | ALDH1A1PDE3BPDE3ATSHRLMNA | |
| Cilostazol SCHEMBL16128 | 0.83 | PDE3B (1.00) | ALDH1A1PDE3BPDE3ATSHRLMNA | |
| Cilostazol SCHEMBL29389547 | 0.83 | PDE3B (1.00) | ALDH1A1PDE3BPDE3ATSHRLMNA | |
| SCHEMBL27646408 | 0.81 | PDE3B (0.64) | ALDH1A1PDE3BPDE3ATSHRLMNA | |
| Cilostazol SCHEMBL5798390 | 0.80 | PDE3B (0.93) | ALDH1A1PDE3BPDE3ATSHRLMNA | |
| SCHEMBL7307973 | 0.80 | PDE3B (0.94) | ALDH1A1PDE3BPDE3ATSHRLMNA | |
| Cilostazol SCHEMBL5798394 | 0.79 | PDE3B (0.92) | ALDH1A1PDE3BPDE3ATSHRLMNA | |
| SCHEMBL24668909 | 0.79 | PDE3B (0.80) | ALDH1A1PDE3BPDE3ATSHRLMNA | |
| SCHEMBL12116425 | 0.79 | PDE3B (0.86) | ALDH1A1PDE3BPDE3ATSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090053168-A1 | TREATMENTS OF B-CELL PROLIFERATIVE DISORDERS | ZALICUS INC. | 2009-02-26 | — | — | US | disclosed |
| US-20090047243-A1 | COMBINATIONS FOR THE TREATMENT OF B-CELL PROLIFERATIVE DISORDERS | ZALICUS INC. | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090047243-A1 | COMBINATIONS FOR THE TREATMENT OF B-CELL PROLIFERATIVE DISORDERS | ADORA2A, PDE4A, PDE4D | ALDH1A1 1368/4885PDE3B 15/4885PDE3A 18/4885 |
| US-20090053168-A1 | TREATMENTS OF B-CELL PROLIFERATIVE DISORDERS | BCL6, BCL6B, BCL3 | ALDH1A1 1378/4885PDE3B 21/4885PDE3A 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.