Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 0.70 |
| ▸ | DPP8 | Q6V1X1 | 11/20 | 0.70 |
| ▸ | DPP7 | Q9UHL4 | 10/20 | 0.70 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.66 |
| ▸ | FAP | Q12884 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3844868 | 0.88 | DPP4 (0.75) | DPP4DPP8DPP7DPP9FAP | |
| Hydrochloric Acid SCHEMBL2708914 | 0.86 | DPP4 (0.77) | DPP4DPP8DPP7DPP9 | |
| Hydrochloric Acid SCHEMBL5987720 | 0.86 | DPP4 (0.77) | DPP4DPP8DPP7DPP9 | |
| SCHEMBL3849234 | 0.84 | DPP4 (0.79) | DPP4DPP8DPP7DPP9FAP | |
| SCHEMBL3846398 | 0.83 | DPP4 (1.00) | DPP4DPP8DPP7DPP9FAP | |
| Hydrochloric Acid SCHEMBL2708932 | 0.82 | DPP4 (0.98) | DPP4DPP8DPP9 | |
| SCHEMBL3845470 | 0.81 | DPP4 (0.77) | DPP4DPP8DPP7DPP9FAP | |
| SCHEMBL3841908 | 0.81 | DPP4 (1.00) | DPP4DPP8DPP7DPP9FAP | |
| Gosogliptin SCHEMBL23715004 | 0.80 | DPP4 (1.00) | DPP4DPP8DPP7DPP9FAP | |
| Gosogliptin SCHEMBL197108 | 0.80 | DPP4 (1.00) | DPP4DPP8DPP7DPP9FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856065-B1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PF MEDICAMENT (FR) | 2009-11-11 | — | — | EP | claimed |
| EP-2116541-B1 | Proline derivatives and their use as dipeptidyl peptidase IV inhibitors | PFIZER PROD INC (US) | 2015-02-25 | — | — | EP | disclosed |
| EP-2116541-A1 | Proline derivatives and their use as dipeptidyl peptidase IV inhibitors | Pfizer Products Incorporated (US) | 2009-11-11 | — | — | EP | disclosed |