Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Gosogliptin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 known ✓ | P27487 | 20/20 | 1.00 |
| ▸ | DPP8 | Q6V1X1 | 14/20 | 1.00 |
| ▸ | DPP7 | Q9UHL4 | 14/20 | 1.00 |
| ▸ | FAP | Q12884 | 1/20 | 1.00 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gosogliptin SCHEMBL197108 | 1.00 | DPP4 (1.00) | DPP4DPP8DPP7FAPDPP9 | |
| SCHEMBL3848283 | 0.93 | DPP4 (1.00) | DPP4DPP8DPP7FAPDPP9 | |
| SCHEMBL3842688 | 0.90 | DPP4 (0.81) | DPP4DPP8DPP7FAPDPP9 | |
| SCHEMBL14648442 | 0.90 | DPP4 (0.81) | DPP4DPP8DPP7FAPDPP9 | |
| SCHEMBL3849234 | 0.88 | DPP4 (0.79) | DPP4DPP8DPP7FAPDPP9 | |
| SCHEMBL3842662 | 0.88 | DPP4 (0.78) | DPP4DPP8DPP7FAPDPP9 | |
| Hydrochloric Acid SCHEMBL3841151 | 0.87 | DPP4 (0.98) | DPP4DPP8DPP7FAPDPP9 | |
| Hydrochloric Acid SCHEMBL3841149 | 0.87 | DPP4 (0.98) | DPP4DPP8DPP7FAPDPP9 | |
| SCHEMBL3840932 | 0.87 | DPP4 (0.77) | DPP4DPP8DPP7FAPDPP9 | |
| SCHEMBL3845134 | 0.86 | DPP4 (0.75) | DPP4DPP8DPP7FAPDPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3782649-B1 | BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS | ASCENDIS PHARMA AS (DK) | 2025-05-14 | — | — | EP | disclosed |
| US-20230381323-A1 | RELEASABLE CONJUGATES | FISH & RICHARDSON PC | 2023-11-30 | — | — | US | disclosed |
| US-11786599-B2 | Releasable conjugates | QUIAPEG PHARMACEUTICALS AB (SE) | 2023-10-17 | — | — | US | disclosed |
| US-20230123784-A1 | Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels | ASCENDIS PHARMA A/S (DK) | 2023-04-20 | — | — | US | disclosed |
| US-11559482-B2 | Biodegradable polyethylene glycol based water-insoluble hydrogels | ASCENDIS PHARMA A/S (DE) | 2023-01-24 | — | — | US | disclosed |
| EP-4011396-A1 | RELEASABLE CONJUGATES | QuiaPEG Pharmaceuticals AB (SE) | 2022-06-15 | — | — | EP | disclosed |
| WO-2021151251-A1 | TREATING TREATMENT-RESISTANT DIABETES WITH GLUCOKINASE ACTIVATOR | HUA MEDICINE (SHANGHAI) LTD. (CN) | 2021-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230123784-A1 | Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels | PLG, PHYKPL, PLOD3 | DPP4 1529/4885DPP8 1418/4885DPP7 1236/4885 |
| US-20230381323-A1 | RELEASABLE CONJUGATES | GUSB, ABCB11, UGT2B7 | DPP4 828/4885DPP8 955/4885DPP7 499/4885 |
| US-11559482-B2 | Biodegradable polyethylene glycol based water-insoluble hydrogels | PLG, PHYKPL, PLOD3 | DPP4 1529/4885DPP8 1418/4885DPP7 1236/4885 |
| US-11786599-B2 | Releasable conjugates | GUSB, ABCB11, UGT2B7 | DPP4 828/4885DPP8 955/4885DPP7 499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.