Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 9/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 9/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | EIF4E | P06730 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 2/20 | 0.43 |
| ▸ | GRK5 | P34947 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.40 |
| ▸ | AKT1 | P31749 | 2/20 | 0.40 |
| ▸ | AKT2 | P31751 | 2/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.37 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3848374 | 0.89 | FYN (0.45) | MKNK1MKNK2FYNGRK5TGFBR1 | |
| SCHEMBL3845957 | 0.87 | FLT3 (0.41) | MKNK1MKNK2CYP3A4EIF4ETGFBR1 | |
| SCHEMBL3846841 | 0.86 | TGFBR1 (0.48) | MKNK1MKNK2FYNGRK5TGFBR1 | |
| SCHEMBL3848269 | 0.85 | KCNH2 (0.48) | MKNK1MKNK2CYP3A4EIF4ETGFBR1 | |
| SCHEMBL3844884 | 0.84 | MKNK1 (0.41) | MKNK1MKNK2CYP3A4EIF4EFYN | |
| SCHEMBL3845550 | 0.81 | FLT3 (0.41) | MKNK1MKNK2FYNGRK5TGFBR1 | |
| SCHEMBL13874519 | 0.79 | MKNK1 (0.51) | MKNK1MKNK2CYP3A4EIF4EFYN | |
| SCHEMBL3847225 | 0.79 | TGFBR1 (0.43) | MKNK1MKNK2FYNTGFBR1 | |
| Hydrochloric Acid SCHEMBL3850553 | 0.79 | MKNK1 (0.50) | MKNK1MKNK2CYP3A4EIF4EFYN | |
| SCHEMBL3847151 | 0.78 | FLT3 (0.41) | MKNK1MKNK2CYP3A4EIF4ETGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |