Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 18/20 | 0.73 |
| ▸ | KDR | P35968 | 4/20 | 0.73 |
| ▸ | AXL | P30530 | 3/20 | 0.62 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.62 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5825359 | 0.93 | MET (0.85) | METKDRAXLPDGFRAPDGFRB | |
| SCHEMBL1876024 | 0.92 | MET (0.86) | METKDRAXLPDGFRAPDGFRB | |
| SCHEMBL5825837 | 0.88 | PDGFRA (0.71) | METKDRAXLPDGFRAKIT | |
| SCHEMBL1882679 | 0.87 | MET (0.73) | METKDRAXLPDGFRAPDGFRB | |
| SCHEMBL1874823 | 0.87 | MET (0.75) | METKDRAXLPDGFRAPDGFRB | |
| SCHEMBL1879923 | 0.87 | MET (0.75) | METKDRAXLPDGFRAPDGFRB | |
| SCHEMBL1879278 | 0.86 | MET (0.87) | METKDRAXLPDGFRAPDGFRB | |
| SCHEMBL5825378 | 0.86 | MET (0.68) | METKDRAXLPDGFRAPDGFRB | |
| SCHEMBL1875675 | 0.85 | MET (0.83) | METKDRAXLPDGFRAPDGFRB | |
| SCHEMBL1877132 | 0.85 | MET (0.72) | METKDRAXLPDGFRAPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411046-B1 | QUINOLINE DERIVATIVE AND QUINAZOLINE DERIVATIVE INHIBITING SELF-PHOSPHORYLATION OF HEPATOCYTUS PROLIFERATOR RECEPTOR, AND MEDICINAL COMPOSITION CONTAINING THE SAME | KIRIN PHARMA KK (JP) | 2009-09-16 | — | — | EP | claimed |