Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 16/20 | 0.53 |
| ▸ | MMP1 | P03956 | 3/20 | 0.48 |
| ▸ | MMP3 | P08254 | 3/20 | 0.48 |
| ▸ | MMP7 | P09237 | 3/20 | 0.48 |
| ▸ | MMP9 | P14780 | 3/20 | 0.48 |
| ▸ | MMP8 | P22894 | 3/20 | 0.48 |
| ▸ | MMP13 | P45452 | 3/20 | 0.48 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | GPR183 | P32249 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL387399 | 0.92 | GPR119 (0.60) | GPR119MMP1MMP3MMP7MMP9 | |
| SCHEMBL388696 | 0.92 | GPR119 (0.60) | GPR119MMP1MMP3MMP7MMP9 | |
| SCHEMBL387326 | 0.86 | GPR119 (0.47) | GPR119MMP1MMP3MMP7MMP9 | |
| SCHEMBL386769 | 0.83 | GPR119 (0.56) | GPR119MMP1MMP3MMP7MMP9 | |
| SCHEMBL387411 | 0.83 | GPR119 (0.56) | GPR119MMP1MMP3MMP7MMP9 | |
| SCHEMBL388367 | 0.83 | GPR119 (0.56) | GPR119MMP1MMP3MMP7MMP9 | |
| SCHEMBL387949 | 0.80 | GPR119 (0.46) | GPR119MMP1MMP3MMP7MMP9 | |
| SCHEMBL388629 | 0.80 | GPR119 (0.51) | GPR119GPR183 | |
| SCHEMBL385351 | 0.80 | GPR119 (0.51) | GPR119GPR183 | |
| SCHEMBL388679 | 0.80 | GPR119 (0.51) | GPR119GPR183 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094683-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SmithKline Beecham Corporation (US) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008070692-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-12 | — | — | WO | disclosed |