SCHEMBL3845673

SCHEMBL3845673

CCCC(O)(CN[C@@H](C)c1ccccc1)c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APAF1 O14727 1/20 0.43
CYP3A4 P08684 2/20 0.42
CHRM2 P08172 1/20 0.42
HTR1A P08908 1/20 0.42
ADRA2A P08913 1/20 0.42
ADORA3 P0DMS8 1/20 0.42
CHRM1 P11229 1/20 0.42
SMPD1 P17405 1/20 0.42
DRD1 P21728 1/20 0.42
TBXA2R P21731 1/20 0.42
SLC6A2 P23975 1/20 0.42
SLC6A4 P31645 1/20 0.42
ADRA1A P35348 1/20 0.42
OPRM1 P35372 1/20 0.42
DRD3 P35462 1/20 0.42
CASR P41180 1/20 0.42
HTR2B P41595 1/20 0.42
SLC6A3 Q01959 1/20 0.42
KCNH2 Q12809 1/20 0.42
LMNA P02545 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2065865 1.00 APAF1 (0.43) APAF1CYP3A4CHRM2HTR1AADRA2A
SCHEMBL2066806 1.00 APAF1 (0.43) APAF1CYP3A4CHRM2HTR1AADRA2A
SCHEMBL19616773 0.78 CYP3A4 (0.47) APAF1CYP3A4CHRM2HTR1AADRA2A
SCHEMBL14943969 0.77 CYP2C19 (0.42) CHRM2CHRM1KCNH2LMNACYP1A2
SCHEMBL16791656 0.76 SMN1; SMN2 (0.42) CYP3A4CHRM2HTR1AADRA2AADORA3
SCHEMBL9194705 0.76 CYP2C19 (0.52) CHRM2CHRM1LMNACYP1A2CYP2C19
SCHEMBL3825799 0.76 CYP2C19 (0.41) CHRM2CHRM1LMNACYP1A2CYP2C19
SCHEMBL1902599 0.74 SMN1; SMN2 (0.43) APAF1CYP3A4CHRM2HTR1AADRA2A
SCHEMBL12670498 0.73 SMN1; SMN2 (0.42) APAF1CYP3A4CHRM2HTR1AADRA2A
SCHEMBL23014014 0.73 CYP2C19 (0.48) CYP3A4CHRM2CHRM1OPRM1DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2099794-A2 THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS Bristol-Myers Squibb Company (US) 2009-09-16 EP disclosed
WO-2008079873-A2 THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2008-07-03 WO disclosed
WO-2008079873-A2 THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2008-07-03 WO disclosed