Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 14/20 | 0.78 |
| ▸ | CASP3 | P42574 | 1/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.78 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | AOC1 | P19801 | 2/20 | 0.49 |
| ▸ | NT5E | P21589 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3625650 | 0.88 | KIF11 (1.00) | KIF11CASP3KCNH2MAOBAOC1 | |
| SCHEMBL17151556 | 0.88 | KIF11 (1.00) | KIF11CASP3KCNH2MAOBAOC1 | |
| SCHEMBL13315433 | 0.84 | KIF11 (0.58) | KIF11CASP3KCNH2NT5E | |
| SCHEMBL3625796 | 0.84 | KIF11 (0.58) | KIF11CASP3KCNH2NT5E | |
| SCHEMBL3624174 | 0.82 | KIF11 (1.00) | KIF11CASP3KCNH2MAOBNT5E | |
| SCHEMBL3621249 | 0.81 | KIF11 (0.80) | KIF11CASP3KCNH2MAOBAOC1 | |
| SCHEMBL17323004 | 0.79 | KIF11 (0.80) | KIF11CASP3KCNH2MAOBAOC1 | |
| SCHEMBL3624136 | 0.78 | KIF11 (0.81) | KIF11CASP3KCNH2 | |
| SCHEMBL3624192 | 0.74 | KIF11 (0.78) | KIF11CASP3KCNH2MAOBNT5E | |
| SCHEMBL5672186 | 0.73 | KIF11 (0.71) | KIF11CASP3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492487-B1 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2009-11-11 | — | — | EP | claimed |