Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 3/20 | 0.45 |
| ▸ | FYN | P06241 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3851429 | 0.88 | MAP4K4 (0.43) | FYNATMALDH1A1KDM4ECLK1 | |
| SCHEMBL3850019 | 0.83 | L3MBTL1 (0.41) | BRS3FYNATML3MBTL1ALDH1A1 | |
| SCHEMBL13874620 | 0.81 | FYN (0.44) | BRS3FYNATML3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3847766 | 0.81 | FLT3 (0.52) | FYNCLK1DYRK1ARIPK2PRMT5 | |
| SCHEMBL3849352 | 0.76 | L3MBTL1 (0.42) | FYNATML3MBTL1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL3854393 | 0.76 | FLT3 (0.42) | FYNATMALDH1A1KDM4ETGFBR1 | |
| SCHEMBL3855071 | 0.74 | CLK1 (0.52) | CLK1DYRK1AMEN1KMT2A | |
| SCHEMBL13874137 | 0.74 | FLT3 (0.51) | FYNTGFBR1CLK1DYRK1APRMT5 | |
| Hydrochloric Acid SCHEMBL3851251 | 0.74 | RIPK2 (0.44) | FYNCLK1DYRK1ARIPK2PRMT5 | |
| Hydrochloric Acid SCHEMBL3856691 | 0.73 | FLT3 (0.50) | FYNTGFBR1CLK1DYRK1APRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |