Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.31 |
| ▸ | JAK2 | O60674 | 2/20 | 0.30 |
| ▸ | JAK3 | P52333 | 2/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3849108 | 0.95 | PIK3CA (0.36) | PIK3CAMAPK14PIK3CBMTORCDK19 | |
| SCHEMBL3856381 | 0.93 | PIK3CA (0.33) | PIK3CAPIK3CBMTORCDK19TGFBR1 | |
| SCHEMBL3854701 | 0.90 | PIK3CA (0.37) | PIK3CAMAPK14PIK3CBMTORCDK19 | |
| SCHEMBL3851333 | 0.89 | PIK3CA (0.36) | PIK3CAPIK3CBMTORCDK19TGFBR1 | |
| SCHEMBL3846836 | 0.88 | TGFBR1 (0.32) | PIK3CAPIK3CBMTORCDK19TGFBR1 | |
| SCHEMBL3846502 | 0.86 | PIK3CA (0.40) | PIK3CAMAPK14PIK3CBMTORCDK19 | |
| SCHEMBL3847509 | 0.86 | PIK3CA (0.40) | PIK3CAPIK3CBMTORCDK19TGFBR1 | |
| SCHEMBL3852560 | 0.85 | PIK3CA (0.31) | PIK3CAPIK3CBMTORCDK19 | |
| SCHEMBL3847654 | 0.85 | PIK3CA (0.34) | PIK3CAPIK3CBMTORCDK19 | |
| SCHEMBL3848863 | 0.84 | PIK3CA (0.33) | PIK3CAPIK3CBMTORCDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |