Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 2/20 | 0.54 |
| ▸ | NCF1 | P14598 | 2/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | NMT1 | P30419 | 2/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13874071 | 0.87 | CHRM4 (0.54) | CHRM4NCF1SLC22A12NMT1HTR6 | |
| SCHEMBL3848440 | 0.87 | CHRM4 (0.52) | CHRM4NCF1SLC22A12NMT1HTR6 | |
| SCHEMBL13874000 | 0.84 | CHRM4 (0.56) | CHRM4NCF1 | |
| SCHEMBL3845658 | 0.84 | CHRM4 (0.56) | CHRM4 | |
| SCHEMBL3847011 | 0.84 | CHRM4 (0.56) | CHRM4NCF1SMN1; SMN2 | |
| SCHEMBL3848074 | 0.82 | NCF1 (0.48) | CHRM4NCF1SLC22A12NMT1HTR6 | |
| Hydrochloric Acid SCHEMBL3848380 | 0.82 | CHRM4 (0.50) | CHRM4NCF1GPR119PRKAA2HTR6 | |
| SCHEMBL13874532 | 0.80 | CHRM4 (0.49) | CHRM4NCF1GPR119PRKAA2HTR6 | |
| Hydrochloric Acid SCHEMBL3846951 | 0.80 | CHRM4 (0.49) | CHRM4NCF1GPR119PRKAA2HTR6 | |
| SCHEMBL14145381 | 0.80 | CHRM4 (0.52) | CHRM4NCF1SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |