Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 18/20 | 0.59 |
| ▸ | DPP7 | Q9UHL4 | 11/20 | 0.59 |
| ▸ | DPP8 | Q6V1X1 | 10/20 | 0.59 |
| ▸ | FAP | Q12884 | 2/20 | 0.59 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.59 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2711784 | 0.80 | DPP4 (0.71) | DPP4 | |
| SCHEMBL3844334 | 0.79 | DPP4 (0.65) | DPP4DPP7DPP8FAPDPP9 | |
| SCHEMBL1182778 | 0.78 | MEN1 (0.56) | DPP4DPP7KDM1A | |
| SCHEMBL27109887 | 0.78 | SMN1; SMN2 (0.51) | DPP4HRH3 | |
| SCHEMBL3843422 | 0.77 | PARP1 (0.42) | DPP4DPP7KDM1A | |
| SCHEMBL31556628 | 0.76 | MEN1 (0.62) | DPP4DPP7KDM1A | |
| SCHEMBL30919465 | 0.76 | SMN1; SMN2 (0.53) | DPP4DPP7DPP8DPP9HRH3 | |
| SCHEMBL3849234 | 0.76 | DPP4 (0.79) | DPP4DPP7DPP8FAPDPP9 | |
| SCHEMBL3848903 | 0.76 | DPP4 (0.59) | DPP4DPP7DPP8FAPDPP9 | |
| SCHEMBL3844323 | 0.75 | DPP4 (0.67) | DPP4DPP7DPP8FAPDPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2116541-B1 | Proline derivatives and their use as dipeptidyl peptidase IV inhibitors | PFIZER PROD INC (US) | 2015-02-25 | — | — | EP | disclosed |
| EP-2116541-A1 | Proline derivatives and their use as dipeptidyl peptidase IV inhibitors | Pfizer Products Incorporated (US) | 2009-11-11 | — | — | EP | disclosed |