Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.59 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | MTOR | P42345 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19585798 | 0.82 | MAP3K14 (0.56) | MAP3K14FLT3PIK3CAMTORCHEK1 | |
| SCHEMBL15756965 | 0.80 | MAP3K14 (0.54) | MAP3K14FLT3PIK3CAMTORCHEK1 | |
| SCHEMBL1615002 | 0.80 | MAP3K14 (0.62) | MAP3K14FLT3PIK3CAMTORCHEK1 | |
| SCHEMBL26178953 | 0.78 | KDR (0.53) | MAP3K14FLT3PIK3CAMTORNPC1 | |
| SCHEMBL4254179 | 0.76 | MAP3K14 (0.56) | MAP3K14FLT3PIK3CAMTORGAA | |
| SCHEMBL1614011 | 0.75 | MAP3K14 (1.00) | MAP3K14FLT3PIK3CAMTORGSK3B | |
| SCHEMBL3491081 | 0.74 | TGFBR1 (0.46) | FLT3KDM4EGAANPC1SMN1; SMN2 | |
| SCHEMBL19586833 | 0.73 | PIK3CA (0.50) | MAP3K14FLT3PIK3CAMTORCHEK1 | |
| SCHEMBL3491776 | 0.73 | IRAK4 (0.47) | FLT3KDM4EGAANPC1SMN1; SMN2 | |
| SCHEMBL15288131 | 0.71 | FYN (0.55) | MAP3K14FLT3PIK3CAMTORKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |