SCHEMBL3846887

SCHEMBL3846887

Cc1ccc([PH](=O)O)cc1Cl

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.43
SMN1; SMN2 Q16637 6/20 0.38
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
HPGD P15428 4/20 0.37
KDM4E B2RXH2 1/20 0.37
HTT P42858 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
MAPT P10636 3/20 0.36
HTR3E A5X5Y0 1/20 0.36
HTR3B O95264 1/20 0.36
HTR3A P46098 1/20 0.36
HTR3D Q70Z44 1/20 0.36
HTR3C Q8WXA8 1/20 0.36
ALDH1A1 P00352 4/20 0.36
GFER P55789 1/20 0.36
CHRNA1 P02708 1/20 0.36
CHRNG P07510 1/20 0.36
CHRNB1 P11230 1/20 0.36
CHRNB2 P17787 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28408749 0.80 PRSS1 (0.40) SMN1; SMN2NPC1RAB9AHTTL3MBTL1
SCHEMBL21112088 0.72
SCHEMBL4340369 0.68 SMN1; SMN2 (0.40) CYP3A4SMN1; SMN2HPGDMAPT
SCHEMBL15820155 0.68 ESR1 (0.38) SMN1; SMN2MAPTALDH1A1GAA
SCHEMBL21112089 0.68
SCHEMBL230854 0.67 TDP1 (0.44) SMN1; SMN2HPGDHTTALDH1A1GAA
SCHEMBL15304564 0.67 LMNA (0.44) CYP3A4NPC1L3MBTL1ALDH1A1
SCHEMBL15820158 0.67 ESR1 (0.37) MAPTALDH1A1GAA
SCHEMBL10778405 0.67 HPGD (0.51) CYP3A4SMN1; SMN2NPC1RAB9AHPGD
Ammonia Solution, Strong SCHEMBL17670037 0.66 TDP1 (0.42) SMN1; SMN2HPGDHTTALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013142328-A1 SMALL MOLECULE ANTAGONISTS OF PF4 CONTAINING ULTRA LARGE COMPLEXES THE TRUSTEES OF THE UNIVERSITY OF PENSYLVANIA (US) 2013-09-26 WO disclosed
WO-2013142328-A1 SMALL MOLECULE ANTAGONISTS OF PF4 CONTAINING ULTRA LARGE COMPLEXES THE TRUSTEES OF THE UNIVERSITY OF PENSYLVANIA (US) 2013-09-26 WO disclosed
WO-2009033183-A2 COMPOUNDS AND METHODS FOR TREATMENT OF HCV AND CONDITIONS ASSOCIATED WITH CD81 BINDING UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) 2009-03-12 WO disclosed