Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 13/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 13/20 | 0.41 |
| ▸ | EIF4E | P06730 | 3/20 | 0.37 |
| ▸ | MLYCD | O95822 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.36 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3846417 | 0.88 | MKNK1 (0.53) | MKNK1MKNK2EIF4ETGFBR1IRAK4 | |
| SCHEMBL3851211 | 0.85 | SLC2A1 (0.38) | MKNK1MKNK2EIF4ETGFBR1TGFBR2 | |
| SCHEMBL3849616 | 0.84 | TGFBR1 (0.39) | TGFBR1TGFBR2 | |
| SCHEMBL3847225 | 0.81 | TGFBR1 (0.43) | MKNK1MKNK2TGFBR1TGFBR2 | |
| SCHEMBL3852272 | 0.80 | TGFBR1 (0.41) | MKNK1MKNK2TGFBR1TGFBR2 | |
| SCHEMBL3845039 | 0.80 | TGFBR1 (0.46) | TGFBR1TGFBR2ALDH1A1 | |
| SCHEMBL3846841 | 0.80 | TGFBR1 (0.48) | MKNK1MKNK2TGFBR1TGFBR2IRAK4 | |
| SCHEMBL4712454 | 0.80 | TGFBR1 (0.39) | TGFBR1TGFBR2 | |
| SCHEMBL3848725 | 0.79 | TGFBR1 (0.45) | MKNK1TGFBR1TGFBR2 | |
| SCHEMBL3850395 | 0.79 | TGFBR1 (0.38) | TGFBR1TGFBR2KDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |