Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PRNP | P04156 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 7/20 | 0.46 |
| ▸ | RPS6KB2 | Q9UBS0 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ADK | P55263 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14843470 | 0.79 | ADORA2A (0.57) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL4201167 | 0.78 | ERN1 (0.40) | MEN1KMT2AALDH1A1KDM4ERPS6KB2 | |
| SCHEMBL4205381 | 0.78 | RPS6KB2 (0.39) | SMN1; SMN2RPS6KB2ADKRIPK2RIPK3 | |
| SCHEMBL19092124 | 0.78 | RPS6KB2 (0.64) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL28872939 | 0.74 | SMN1; SMN2 (0.63) | SMN1; SMN2MEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL183245 | 0.73 | CLK4 (0.60) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL3120320 | 0.73 | SMN1; SMN2 (0.54) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL3851637 | 0.72 | ACVR1 (0.46) | ALDH1A1KDM4ECYP1A2CYP2C19HPGD | |
| SCHEMBL182899 | 0.72 | PIK3CD (0.52) | ALDH1A1KDM4ECYP1A2CYP2C19HPGD | |
| SCHEMBL3855542 | 0.72 | SMN1; SMN2 (0.43) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| WO-2009026346-A1 | THIAZOLIDINE COMPOUNDS, AND METHODS OF MAKING AND USING SAME | TARGEGEN INC. (US) | 2009-02-26 | — | — | WO | disclosed |
| WO-2009026346-A1 | THIAZOLIDINE COMPOUNDS, AND METHODS OF MAKING AND USING SAME | TARGEGEN INC. (US) | 2009-02-26 | — | — | WO | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |