Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.40 |
| ▸ | RPS6KB2 | Q9UBS0 | 6/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | STK17B | O94768 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4205381 | 0.86 | RPS6KB2 (0.39) | ERN1RPS6KB2PDE3BPDE3ARIPK2 | |
| SCHEMBL4347432 | 0.79 | PIM1 (0.53) | NPC1 | |
| SCHEMBL4194056 | 0.79 | PIM1 (0.53) | NPC1 | |
| SCHEMBL4194057 | 0.79 | PIM1 (0.53) | NPC1 | |
| SCHEMBL3847485 | 0.78 | SMN1; SMN2 (0.54) | RPS6KB2RIPK2RIPK3KDM4EMEN1 | |
| SCHEMBL4191687 | 0.78 | TOP2A (0.43) | ERN1KDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL2882073 | 0.77 | ADORA2A (0.57) | KDM4EMEN1NPC1ALDH1A1POLB | |
| SCHEMBL4199482 | 0.76 | RIPK2 (0.39) | RIPK2RIPK3KDM4EMEN1NPC1 | |
| SCHEMBL14843470 | 0.76 | ADORA2A (0.57) | RPS6KB2PDE3BPDE3AKDM4EMEN1 | |
| SCHEMBL4194980 | 0.75 | ERN1 (0.38) | ERN1KDM4EMEN1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026346-A1 | THIAZOLIDINE COMPOUNDS, AND METHODS OF MAKING AND USING SAME | TARGEGEN INC. (US) | 2009-02-26 | — | — | WO | disclosed |
| WO-2009026346-A1 | THIAZOLIDINE COMPOUNDS, AND METHODS OF MAKING AND USING SAME | TARGEGEN INC. (US) | 2009-02-26 | — | — | WO | disclosed |