Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 11/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 11/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | EIF4E | P06730 | 1/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3846712 | 0.87 | MKNK1 (0.61) | MKNK1MKNK2PIK3CAMTORMAP3K14 | |
| SCHEMBL13874025 | 0.85 | PIK3CA (0.44) | MKNK1MKNK2PIK3CAMTORMAP3K14 | |
| SCHEMBL3850100 | 0.85 | PIK3CA (0.53) | MKNK1MKNK2PIK3CAMTORMAP3K14 | |
| SCHEMBL14145116 | 0.83 | ATM (0.63) | MKNK1MKNK2PIK3CAMTORMAP3K14 | |
| SCHEMBL18609372 | 0.82 | PIK3CA (0.52) | MKNK1MKNK2PIK3CAMTORFYN | |
| SCHEMBL15285823 | 0.82 | MKNK1 (0.50) | MKNK1MKNK2FYNATMCYP3A4 | |
| SCHEMBL26178953 | 0.81 | KDR (0.53) | MKNK1MKNK2PIK3CAMTORMAP3K14 | |
| SCHEMBL15756965 | 0.81 | MAP3K14 (0.54) | MKNK1MKNK2PIK3CAMTORMAP3K14 | |
| SCHEMBL15288077 | 0.79 | MKNK1 (0.68) | MKNK1MKNK2PIK3CACYP3A4EIF4E | |
| SCHEMBL3846577 | 0.79 | RIPK2 (0.45) | PIK3CAMTORMAP3K14FYNALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |