Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.61 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.61 |
| ▸ | FYN | P06241 | 10/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.49 |
| ▸ | GRK5 | P34947 | 2/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | ATR | Q13535 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | EIF4E | P06730 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3847512 | 0.87 | MKNK1 (0.51) | MKNK1MKNK2FYNMAP3K14PIK3CA | |
| SCHEMBL15288071 | 0.84 | MKNK1 (0.67) | MKNK1MKNK2FYNRIPK2GRK5 | |
| SCHEMBL24460479 | 0.83 | MKNK1 (0.73) | MKNK1MKNK2FYNRIPK2CYP3A4 | |
| SCHEMBL3850100 | 0.83 | PIK3CA (0.53) | MKNK1MKNK2FYNRIPK2MAP3K14 | |
| SCHEMBL13874025 | 0.83 | PIK3CA (0.44) | MKNK1MKNK2FYNMAP3K14PIK3CA | |
| SCHEMBL18584581 | 0.82 | MKNK1 (0.57) | MKNK1MKNK2FYNRIPK2PIK3CA | |
| SCHEMBL14145116 | 0.82 | ATM (0.63) | MKNK1MKNK2FYNMAP3K14PIK3CA | |
| SCHEMBL15718042 | 0.80 | MKNK1 (0.90) | MKNK1MKNK2FYNATM | |
| SCHEMBL3854262 | 0.78 | FYN (0.52) | FYN | |
| SCHEMBL21084989 | 0.77 | TGFBR1 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |