Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 16/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 16/20 | 0.45 |
| ▸ | EIF4E | P06730 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3848240 | 0.94 | MKNK1 (0.37) | MKNK1MKNK2EIF4EKDR | |
| SCHEMBL3845931 | 0.88 | KDR (0.39) | MKNK1MKNK2EIF4EALDH1A1RAB9A | |
| SCHEMBL3845847 | 0.85 | KDR (0.37) | MKNK1MKNK2ALDH1A1NPC1RAB9A | |
| SCHEMBL3844458 | 0.85 | KDR (0.37) | MKNK1MKNK2KDR | |
| SCHEMBL3849894 | 0.83 | TGFBR1 (0.36) | ALDH1A1NPC1MAPTPKMRAB9A | |
| Hydrochloric Acid SCHEMBL3854633 | 0.81 | MKNK1 (0.47) | MKNK1MKNK2EIF4EALDH1A1NPC1 | |
| SCHEMBL3846039 | 0.79 | KDR (0.39) | MKNK1MKNK2KDR | |
| SCHEMBL3847138 | 0.77 | KDR (0.37) | KDR | |
| SCHEMBL3848204 | 0.76 | KDR (0.41) | KDR | |
| SCHEMBL3852056 | 0.76 | KDR (0.41) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |