Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 14/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.57 |
| ▸ | PDE4A | P27815 | 2/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RGS12 | O14924 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1892013 | 0.85 | POLB (0.49) | ADORA2BADORA3ADORA2APDE4APDE4B | |
| SCHEMBL2958489 | 0.85 | ADORA2B (0.58) | ADORA2BADORA3ADORA2APDE4APDE4B | |
| SCHEMBL27499964 | 0.82 | ADORA2B (0.62) | ADORA2BADORA3ADORA2APDE4APDE4B | |
| SCHEMBL7618347 | 0.81 | ADORA2B (0.61) | ADORA2BADORA3ADORA2APDE4APDE4B | |
| SCHEMBL7617175 | 0.81 | ADORA2B (0.61) | ADORA2BADORA3ADORA2APDE4APDE4B | |
| SCHEMBL27206789 | 0.81 | ADORA2B (0.59) | ADORA2BADORA3ADORA2APDE4APDE4B | |
| SCHEMBL5831429 | 0.80 | ADORA2B (0.52) | ADORA2BADORA3ADORA2APDE4APDE4B | |
| SCHEMBL8356656 | 0.80 | ADORA2B (0.52) | ADORA2BADORA3ADORA2APDE4APDE4B | |
| SCHEMBL7621629 | 0.78 | ADORA2B (0.57) | ADORA2BADORA3ADORA2APDE4APDE4B | |
| SCHEMBL3848060 | 0.77 | ADORA2A (0.57) | ADORA2BADORA3ADORA2APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090053168-A1 | TREATMENTS OF B-CELL PROLIFERATIVE DISORDERS | ZALICUS INC. | 2009-02-26 | — | — | US | disclosed |
| US-20090047243-A1 | COMBINATIONS FOR THE TREATMENT OF B-CELL PROLIFERATIVE DISORDERS | ZALICUS INC. | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090047243-A1 | COMBINATIONS FOR THE TREATMENT OF B-CELL PROLIFERATIVE DISORDERS | ADORA2A, PDE4A, PDE4D | ADORA2B 24/4885ADORA3 27/4885ADORA2A 1/4885 |
| US-20090053168-A1 | TREATMENTS OF B-CELL PROLIFERATIVE DISORDERS | BCL6, BCL6B, BCL3 | ADORA2B 45/4885ADORA3 101/4885ADORA2A 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.