Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.59 |
| ▸ | PLD1 | Q13393 | 2/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.46 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.46 |
| ▸ | BPTF | Q12830 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP4 | P49662 | 1/20 | 0.43 |
| ▸ | CASP5 | P51878 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16023470 | 0.79 | PIK3CA (0.62) | ALDH1A1 | |
| SCHEMBL13675040 | 0.79 | HRH4 (0.59) | HRH3CASP1KDM4EALDH1A1HRH4 | |
| SCHEMBL30230278 | 0.79 | ADRB1 (0.59) | ADRB1PLD1HRH3DYRK1ABPTF | |
| SCHEMBL22581914 | 0.79 | ADRB1 (0.64) | ADRB1PLD1HRH3DYRK1APRKD3 | |
| SCHEMBL30351053 | 0.79 | ADRB1 (0.59) | ADRB1PLD1HRH3DYRK1APRKD3 | |
| SCHEMBL1026043 | 0.79 | ADRB1 (0.59) | ADRB1PLD1HRH3DYRK1ABPTF | |
| SCHEMBL1558641 | 0.79 | ADRB1 (0.59) | ADRB1PLD1HRH3DYRK1APRKD3 | |
| SCHEMBL19288501 | 0.79 | ADRB1 (0.59) | ADRB1PLD1HRH3DYRK1APRKD3 | |
| SCHEMBL29937735 | 0.79 | ADRB1 (0.59) | ADRB1PLD1HRH3DYRK1ABPTF | |
| SCHEMBL30567171 | 0.79 | ADRB1 (0.64) | ADRB1PLD1HRH3DYRK1APRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-A2 | PYRIDO[2,3-B]PYRAZINE AND[1,8]-NAPHTYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2007130468-A2 | PYRIDO [2, 3-B] PYRAZINE AND [1, 8] -NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2007-11-15 | — | — | WO | disclosed |