Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 4/20 | 0.38 |
| ▸ | GRK5 | P34947 | 2/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 12/20 | 0.37 |
| ▸ | TGFBR2 | P37173 | 9/20 | 0.37 |
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
| ▸ | AKT2 | P31751 | 2/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3845555 | 0.94 | TGFBR1 (0.33) | TGFBR1TGFBR2AKT1AKT2MKNK1 | |
| SCHEMBL3844884 | 0.91 | MKNK1 (0.41) | FYNGRK5TGFBR1AKT1AKT2 | |
| SCHEMBL3846737 | 0.90 | MKNK1 (0.36) | FYNTGFBR1TGFBR2AKT1AKT2 | |
| SCHEMBL3850400 | 0.90 | FLT3 (0.35) | FYNTGFBR1TGFBR2AKT1AKT2 | |
| SCHEMBL3849016 | 0.88 | AKT1 (0.37) | TGFBR1TGFBR2AKT1AKT2 | |
| SCHEMBL3846605 | 0.88 | TGFBR1 (0.37) | TGFBR1TGFBR2 | |
| SCHEMBL3845247 | 0.88 | FLT3 (0.31) | TGFBR1TGFBR2AKT1AKT2 | |
| SCHEMBL3846112 | 0.87 | FLT3 (0.34) | FYNTGFBR1TGFBR2AKT1AKT2 | |
| SCHEMBL3846452 | 0.87 | FLT3 (0.36) | TGFBR1AKT1AKT2 | |
| SCHEMBL3846456 | 0.87 | FLT3 (0.42) | TGFBR1AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |