Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 11/20 | 0.40 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13874263 | 0.75 | MAP3K14 (0.45) | PIK3CAMTORFLT3MAP3K14MKNK1 | |
| SCHEMBL3845076 | 0.74 | FLT3 (0.44) | PIK3CAMTORFLT3MAP3K14MKNK1 | |
| SCHEMBL13873996 | 0.72 | FLT3 (0.43) | PIK3CAMTORFLT3MAP3K14MKNK1 | |
| SCHEMBL3846450 | 0.72 | FLT3 (0.50) | PIK3CAMTORFLT3MAP3K14MKNK1 | |
| SCHEMBL13874265 | 0.69 | SRC (0.46) | PIK3CAMTORFLT3MAP3K14MKNK1 | |
| SCHEMBL3849727 | 0.69 | PIK3CA (0.53) | PIK3CAMTORFLT3MAP3K14 | |
| SCHEMBL3847902 | 0.68 | SLC2A1 (0.47) | PIK3CAMTORFLT3MAP3K14MKNK1 | |
| SCHEMBL19781609 | 0.67 | PIK3CA (0.51) | PIK3CAMTORFLT3MAP3K14 | |
| SCHEMBL2475342 | 0.65 | WRN (0.33) | — | |
| SCHEMBL19586821 | 0.65 | PIK3CA (0.65) | PIK3CAMTORFLT3MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |