Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 6/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.46 |
| ▸ | MET | P08581 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | L3MBTL3 | Q96JM7 | 9/20 | 0.41 |
| ▸ | MBTD1 | Q05BQ5 | 4/20 | 0.41 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.41 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1601003 | 0.81 | ALK (0.74) | ALKL3MBTL1METKDM4EMEN1 | |
| SCHEMBL1600297 | 0.79 | ALK (0.59) | ALKL3MBTL1METKDM4EMEN1 | |
| SCHEMBL12062633 | 0.77 | ALK (0.54) | ALKMET | |
| SCHEMBL12574166 | 0.77 | NTRK1 (0.46) | ALKMETMEN1KMT2A | |
| SCHEMBL1600272 | 0.76 | ALK (0.72) | ALKL3MBTL1METKDM4EMEN1 | |
| SCHEMBL1600401 | 0.75 | ALK (0.70) | ALKL3MBTL1METKDM4EMEN1 | |
| SCHEMBL1602274 | 0.74 | ALK (0.72) | ALKL3MBTL1MKNK1MKNK2L3MBTL3 | |
| SCHEMBL3832876 | 0.73 | L3MBTL1 (0.50) | ALKL3MBTL1METKDM4EMEN1 | |
| SCHEMBL19908272 | 0.73 | ALK (0.53) | ALK | |
| SCHEMBL1601923 | 0.73 | ALK (0.71) | ALKMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-A2 | PYRIDO[2,3-B]PYRAZINE AND[1,8]-NAPHTYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2007130468-A2 | PYRIDO [2, 3-B] PYRAZINE AND [1, 8] -NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2007-11-15 | — | — | WO | disclosed |