Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.42 |
| ▸ | DRD3 | P35462 | 11/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3849784 | 0.88 | DRD2 (0.48) | DRD2DRD3DRD4HTR1AADRA2A | |
| SCHEMBL3843685 | 0.78 | DRD2 (0.52) | DRD2DRD3DRD4HTR1AADRA2A | |
| SCHEMBL3844431 | 0.76 | DRD2 (0.35) | DRD2DRD3HTR1AHTR2AHTR7 | |
| SCHEMBL3848178 | 0.74 | DRD2 (0.60) | DRD2DRD3DRD4 | |
| SCHEMBL3843632 | 0.72 | DRD2 (0.51) | DRD2DRD3HTR1AHTR2AHTR7 | |
| SCHEMBL3851105 | 0.71 | DRD2 (0.47) | DRD2DRD3DRD4HTR1AADRA2A | |
| SCHEMBL3848987 | 0.70 | DRD2 (0.50) | DRD2DRD3CHRM2CHRM1DRD1 | |
| SCHEMBL3845301 | 0.70 | DRD2 (0.50) | DRD2DRD3DRD4CHRM2CHRM1 | |
| SCHEMBL3854012 | 0.69 | DRD2 (0.57) | DRD2DRD3DRD4HTR1AADRA2A | |
| SCHEMBL3854574 | 0.69 | DRD2 (0.52) | DRD2DRD3HTR1AHTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038268-A2 | CARBONYLATED (AZA)CYCLOHEXANES AS DOPAMINE D3 RECEPTOR LIGANDS | BIOPROJET (FR) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007148208-A2 | CARBONYLATED (AZA) CYCLOHEXANES AS DOPAMINE D3 RECEPTOR LIGANDS | BIOPROJET (FR) | 2007-12-27 | — | — | WO | disclosed |