Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Clotrimazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 12/20 | 1.00 |
| ▸ | KCNN4 | O15554 | 3/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 2/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 2/20 | 1.00 |
| ▸ | CCKBR | P32239 | 2/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 1.00 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 1.00 |
| ▸ | KCNA3 | P22001 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | TRPM2 | O94759 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | EGFR | P00533 | 1/20 | 1.00 |
| ▸ | CA2 | P00918 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clotrimazole SCHEMBL29358270 | 1.00 | CYP19A1 (1.00) | CYP19A1KCNN4NR1I2ADORA3TBXA2R | |
| Clotrimazole SCHEMBL1062253 | 1.00 | CYP19A1 (1.00) | CYP19A1KCNN4NR1I2ADORA3TBXA2R | |
| Clotrimazole SCHEMBL6536408 | 0.98 | CYP19A1 (0.97) | CYP19A1KCNN4NR1I2ADORA3TBXA2R | |
| Clotrimazole SCHEMBL7647183 | 0.98 | CYP19A1 (0.97) | CYP19A1KCNN4NR1I2ADORA3TBXA2R | |
| Clotrimazole SCHEMBL12095111 | 0.98 | CYP19A1 (0.97) | CYP19A1KCNN4NR1I2ADORA3TBXA2R | |
| Clotrimazole SCHEMBL6753811 | 0.98 | CYP19A1 (0.97) | CYP19A1KCNN4NR1I2ADORA3TBXA2R | |
| SCHEMBL9720736 | 0.97 | CYP19A1 (0.94) | CYP19A1KCNN4NR1I2ADORA3TBXA2R | |
| SCHEMBL7160183 | 0.92 | CYP19A1 (0.84) | CYP19A1KCNN4NR1I2ADORA3TBXA2R | |
| Clotrimazole SCHEMBL27988836 | 0.92 | CYP19A1 (0.84) | CYP19A1KCNN4NR1I2ADORA3TBXA2R | |
| Clotrimazole SCHEMBL18916739 | 0.92 | CYP19A1 (0.84) | CYP19A1KCNN4NR1I2ADORA3TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 61616 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12636276-B1 | Methods and compositions for treating hemorrhoids | Wang, Jianmin (US) | 2026-05-26 | — | — | US | claimed |
| CN-122075397-A | In-situ foam gel containing exosomes and preparation method and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| WO-2026107113-A1 | MODIFIED CELLS FOR PROGRAMMING EXTRA ENVELOPED VIRUSES (EEVs) AND THEIR USE FOR PRODUCING THE EEVs, THE PROGRAMMED EEVs AND USES THEREOF | CALIDI BIOTHERAPEUTICS (NEVADA), INC. (US) | 2026-05-21 | — | — | WO | claimed |
| WO-2026105160-A1 | NOVEL AGROCHEMICAL COMPOSITION COMPRISING 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS AND USE THEREOF | PI INDUSTRIES LTD. (IN) | 2026-05-21 | — | — | WO | claimed |
| WO-2026106952-A1 | METHODS FOR TREATING CONGENITAL DISORDERS OF GLYCOSYLATION | CDG CARE (US) | 2026-05-21 | — | — | WO | claimed |
| US-12629363-B2 | Prophylaxis and treatment of angioedema | PHARVARIS GMBH (CH) | 2026-05-19 | — | — | US | claimed |
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| EP-4736841-A1 | A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT | IQ medical GmbH (DE) | 2026-05-06 | — | — | EP | claimed |
| US-20260116861-A1 | ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2026-04-30 | — | — | US | claimed |
| US-20260102419-A1 | USE OF COMPOUNDS IN THE TREATMENT OF FUNGAL INFECTIONS | BASILEA PHARMACEUTICA INTERNATIONAL AG, ALLSCHWIL (CH) | 2026-04-16 | — | — | US | claimed |
| EP-0055397-A1 | Antifungal compositions with a high release rate of the drug as an elastic liquid dressing | BAYER AG (DE) | 1982-07-07 | — | — | EP | claimed |
| EP-0054205-A1 | Anti-fungal composition in emulsion form with a higher release rate of the drug | BAYER AG (DE) | 1982-06-23 | — | — | EP | claimed |
| EP-0049468-A1 | Antifungal compositions comprising an antifungal agent and a corticosteroid | SCHERING CORPORATION (US) | 1982-04-14 | — | — | EP | claimed |
| US-4298604-A | FUNGICIDES, ANTIINFLAMMATORY AGENTS | SCHERING CORPORATION (US) | 1981-11-03 | — | — | US | claimed |
| US-4277475-A | FOR BOTH MALES AND FEMALES | SYNTEX (U.S.A.) INC. (US) | 1981-07-07 | — | — | US | claimed |
| US-4267169-A | Novel preparation of clotrimazole | TOKO YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 1981-05-12 | — | — | US | claimed |
| US-4247552-A | Contraceptive compositions and methods employing 1-substituted imidazole derivatives | SYNTEX (U.S.A.) INC. (US) | 1981-01-27 | — | — | US | claimed |
| EP-0007595-A1 | Preparations of clotrimazole and process for preparing same | Toko Yakuhin Kogyo Kabushiki Kaisha (JP) | 1980-02-06 | — | — | EP | claimed |
| US-4073901-A | Metal complexes of N-trityl-azoles for combatting fungi | BAYER AKTIENGESELLSCHAFT (DT) | 1978-02-14 | — | — | US | claimed |
| US-4073922-A | BIS-PHENYL(2-HALOPHENYL)-1-IMIDAZOLYL METHANE | Simoons, John R. A. (US) | 1978-02-14 | — | — | US | claimed |