Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 12/20 | 0.94 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.94 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.94 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.94 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.94 |
| ▸ | CCKBR | P32239 | 2/20 | 0.94 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.94 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.94 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.94 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.94 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.94 |
| ▸ | MEN1 | O00255 | 1/20 | 0.94 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.94 |
| ▸ | GMNN | O75496 | 1/20 | 0.94 |
| ▸ | USP2 | O75604 | 1/20 | 0.94 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.94 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.94 |
| ▸ | EGFR | P00533 | 1/20 | 0.94 |
| ▸ | CA2 | P00918 | 1/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clotrimazole SCHEMBL1062253 | 0.97 | CYP19A1 (1.00) | CYP19A1KCNN4NR1I2ADORA3TBXA2R | |
| Clotrimazole SCHEMBL3850 | 0.97 | CYP19A1 (1.00) | CYP19A1KCNN4NR1I2ADORA3TBXA2R | |
| Clotrimazole SCHEMBL29358270 | 0.97 | CYP19A1 (1.00) | CYP19A1KCNN4NR1I2ADORA3TBXA2R | |
| Clotrimazole SCHEMBL6536408 | 0.95 | CYP19A1 (0.97) | CYP19A1KCNN4NR1I2ADORA3TBXA2R | |
| Clotrimazole SCHEMBL6753811 | 0.95 | CYP19A1 (0.97) | CYP19A1KCNN4NR1I2ADORA3TBXA2R | |
| Clotrimazole SCHEMBL7647183 | 0.95 | CYP19A1 (0.97) | CYP19A1KCNN4NR1I2ADORA3TBXA2R | |
| Clotrimazole SCHEMBL12095111 | 0.95 | CYP19A1 (0.97) | CYP19A1KCNN4NR1I2ADORA3TBXA2R | |
| SCHEMBL7160183 | 0.89 | CYP19A1 (0.84) | CYP19A1KCNN4NR1I2ADORA3TBXA2R | |
| Clotrimazole SCHEMBL27988836 | 0.89 | CYP19A1 (0.84) | CYP19A1KCNN4NR1I2ADORA3TBXA2R | |
| Clotrimazole SCHEMBL18916739 | 0.89 | CYP19A1 (0.84) | CYP19A1KCNN4NR1I2ADORA3TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5149707-A | 1-((2-FLUOROPHENYL)(4-FLUOROPHENYL)PHENYLMETHYL)-1H-IMIDAZOLE USEFUL AS ANTIFUNGAL AGENT | J. URIACH & CIA, S.A. (ES) | 1992-09-22 | — | — | US | disclosed |
| EP-0352352-B1 | 1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole | J. URIACH & CIA. S.A. (ES) | 1991-10-16 | — | — | EP | disclosed |
| EP-0352352-A1 | 1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole | J. URIACH & CIA. S.A. (ES) | 1990-01-31 | — | — | EP | disclosed |